Symposium: Liquid Chromatography Mass Spectrometry: Procedures and Applications
Date: Sunday August 26, 2007
Chair:
Dr. Thomas Kraemer, University of Saarland, Germany (Thomas.kraemer@uniklinikum-saarland.de)
Liquid Chromatography/Mass Spectrometry (LCMS) has become an accessible and widely available technology for forensic toxicologists in the last five years. Although it represents many advantages over other chromatographic techniques, it presents challenges for the development and validation of methods, appropriate selection of the many modes of ionization (MS, MSMS, TOF, etc) and matching the correct analytes to the optimum analytical approach.
This day long symposium will set the scene for many other original research papers to be presented on the topic of LCMS during the meeting, and will not only be a song in praise but will also discuss problems of LC-MS. The speakers are well recognized authorities in this young and dynamic field, who are involved in solving these dilemmas every day in their own laboratories.
The challenges we face daily in use of LCMS include choosing the most appropriate sample preparation techniques, approaches to method optimization, agreeing on acceptable criteria for identification, building and using LCMS libraries, use of screening procedures versus targeted analysis, and when to use GC/MS and when to use LCMS.
Topics for the symposium will include:
- Sample Preparation for LC-MS(/MS) – Always simple?
- Development and Validation of LC-MS(/MS) procedures – Tackling specific problems of LC-MS(/MS)
- Identification and confirmation criteria for LC-MS(/MS) and LC-TOF-MS –Looking beyond the three ion criterion in GC-MS
- General screening procedures using LC-MS(/MS) and LC-TOF-MS – Breaking the shackles of target analysis
- Universal LC-MS Libraries –Reality or Myth?
- Toxicokinetic studies: When do we really need LC-MS(/MS)?
- Fast screening for drugs of abuse using LC-MS – Digging the grave of immunoassay screenings?
- GC/MS or LC/MS – cut-throat competition or peaceful coexistence?